Critical roles of cytokine storm and bacterial infection in patients with COVID‑19: therapeutic potential of mesenchymal stem ce
Critical roles of cytokine storm and bacterial infection in patients with COVID‑19: therapeutic potential of mesenchymal stem cells
This virus can affect all systems of the body and its symptoms vary from a simple upper respiratory infection bacterial co-infection is another problem in COVID-19 which affects the prognosis of patients. pandemic, various approaches and therapeutics were introduced for treating COVID-19 patients. are not helpful enough, especially for complicated cases. Therefore, the therapeutic benefits of mesenchymal stem cells, especially their antimicrobial activity, will help us understand how to treat COVID-19. Herein, mesenchymal stem cells may stop the immune system from becoming overactive in COVID-19 patients.
abstract
The severe acute respiratory syndrome coronavirus 2 has been a shocking disaster for healthcare systems worldwide since
December 2019. This virus can affect all systems of the body and its symptoms vary from a simple upper respiratory infection
to fatal complications including end-organ damage. On the other hand, the normal immune system plays a pivotal role in the
recovery of infectious diseases such as COVID-19. However, occasionally, exaggerated immune system inflammation and
an excessive synthesis of cytokines, known as a "cytokine storm," can deteriorate the patient's clinical condition. Secondary
bacterial co-infection is another problem in COVID-19 which affects the prognosis of patients. Although there are a few
studies about this complication, they suggest not using antibiotics commonly, especially broad-spectrum ones. During this
pandemic, various approaches and therapeutics were introduced for treating COVID-19 patients. However, available treatments
are not helpful enough, especially for complicated cases. Hence, in this era, cell therapy and regenerative medicine
will create new opportunities. Therefore, the therapeutic benefits of mesenchymal stem cells, especially their antimicrobial
activity, will help us understand how to treat COVID-19. Herein, mesenchymal stem cells may stop the immune system from
becoming overactive in COVID-19 patients. On the other side, the stem cells' capacity for repair could encourage natural
.healing processes
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