اولین جلسه کلاس درس «اصول کارآزمایی بالینی» ویژه دانشجویان دکترای تخصصی (PhD) رشته مهندسی بافت (دانشکده علوم و فناوری‌های نوین دانشگاه علوم پزشکی تهران) در مورخ 17/07/1404 در مرکز تحقیقات سلول درمانی و پزشکی بازساختی برگزار شد. این دوره با تدریس اعضای هیئت علمی برجسته حوزه کارآزمایی بالینی و پزشکی بازساختی، با هدف ارتقاء دانش و مهارت‌های لازم برای طراحی و اجرای مطالعات بالینی در حوزه محصولات پزشکی بازساختی (با تمرکز بر محصولات مهندسی بافت) برگزار می‌شود.

Background: Recent studies have shown that obesity is associated with the severity of coronavirus disease (COVID-19). We reviewed clinical studies to clarify the obesity relationship with COVID-19 severity, comorbidities, and discussing possible mechanisms.

Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical applications have received much attention from the global scientific community in an increasing manner. Firstly, MSCs were successfully isolated from human bone marrow (BM), but in the next steps, they were also extracted from other sources, mostly from the umbilical cord (UC) and adipose tissue (AT).

Introduction: Photoaging that is accompanied by gene expression alteration is known as early aging of the skin due to overexposure to natural and/or artificial ultraviolet radiation (UVR). The assessment of gene expression alteration in human primary neonatal dermal fibroblasts depending on recovery time after exposure to solar simulated ultraviolet radiation (ssUVR) is the main aim of this bioinformatic study.

 پژوهش تازه‌ای از دانشگاه کیوتو نشان داده که سلول‌های انسان می‌توانند به امواج صوتی واکنش نشان دهند، قابلیتی که شاید راهی تازه برای مقابله با بیماری‌هایی نظیر چاقی ارائه دهد. دکتر ماساهیرو کومتا، پژوهشگر برجسته در زمینه زیست‌شناسی سلولی و مولکولی و نویسنده اصلی این مطالعه، در گفت‌وگو با اپک تایمز اظهار کرد: «صدا ابزاری منحصر به فرد است که می‌تواند فعالیت‌های سلولی را کنترل کند و تأثیرات گسترده‌ای در زمینه‌های مختلف پزشکی داشته باشد».

Melanoma, a severe type of skin cancer, poses significant management challenges due to its resistance to available treatments. Despite this obstacle, the high immunogenicity of melanoma renders it amenable to immune therapy, and NK cells have been identified as possessing anti-tumor properties in immunotherapy.

Introduction: Metformin is an essential medicine that is most widely prescribed frontline for the treatment of Type 2 diabetes (T2D). Metformin upgraded glycemic control in T2D patients without hypoglycemic effects in patients. This assessment aims to understand molecular mechanism mechanisms in non-responder patients to metformin.

Introduction: Atopic dermatitis is a common inflammatory skin disease which is treated with narrowband ultraviolet B (NB-UVB). Exploring the critical targeted genes in patients by UV radiation is the main aim of this study.

Regenerative medicine represents a transformative approach to treating nucleus pulposus degeneration and offers hope for patients suffering from chronic low back pain due to disc degeneration. By focusing on restoring the natural structure and function of the nucleus pulposus rather than merely alleviating symptoms, these innovative therapies hold the potential to significantly improve patient outcomes.

Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) participate in stem cell proliferation, differentiation, and apoptosis. Sigma-1 receptor (S1R) is a unique ER chaperon protein that regulates ER stress and UPR. Here, we examine the effects of S1R inhibition on pluripotency and differentiation of human embryonic stem cells (hESCs). hESCs were treated with different doses of an S1R inhibitor (BD 1047), and we investigated the expressions of different pluripotency and lineage-specific genes.