Potential role of Sigma-1 receptor inhibition and ER stress-related pathways in upregulating definitive endoderm markers in human embryonic stem cells
https://ctrmrc.tums.ac.ir//article/Potential-role-of-Sigma–1-receptor-inhibition-and-ER-stress–related-pathways-in-upregulating-definitive-endoderm-markers-in-human-embryonic-stem-cells
Potential role of Sigma-1 receptor inhibition and ER stress-related pathways in upregulating definitive endoderm markers in huma Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) participate in stem cell proliferation, differentiation, and apoptosis. Sigma-1 receptor (S1R) is a unique ER chaperon protein that regulates ER stress and UPR. Here, we examine the effects of S1R inhibition on pluripotency and differentiation of human embryonic stem cells (hESCs). hESCs were treated
Application of Biocompatible Scaffolds in Stem-Cell-Based Dental Tissue Engineering
https://ctrmrc.tums.ac.ir//مقالات-علمی/Application-of-Biocompatible-Scaffolds-in-Stem–Cell–Based-Dental-Tissue-Engineering
However, the main focus of literature in the field of dental tissue engineering is on utilizing MSCs. On the other hand, biocompatible scaffolds play a notable role in this regenerative process which is mentioned to be harmless with acceptable osteoinductivity. Also, strategies of tissue bioengineering and experimental models are introduced in order to provide a perspective of the potential roles of dental tissue engineering to be used for clinical aims. Abstract Tissue engineering as an importa
Improved Differentiation of hESC-Derived Pancreatic Progenitors by Using Human Fetal Pancreatic Mesenchymal Cells in a Micro-scalable Three-Dimensional Co-culture System
https://ctrmrc.tums.ac.ir//article/Improved-Differentiation-of-hESC–Derived-Pancreatic-Progenitors-by-Using-Human-Fetal-Pancreatic-Mesenchymal-Cells-in-a-Micro–scalable-Three–Dimensional-Co–culture-System
Improved Differentiation of hESC-Derived Pancreatic Progenitors by Using Human Fetal Pancreatic Mesenchymal Cells in a Micro-sca Therefore, in our study, the impact of three-dimensional (3D) co-culture of human fetal pancreatic-derived mesenchymal cells (hFP-MCs) with human embryonic stem cell-derived pancreatic progenitors (hESC-PPs) development towards endocrine and beta cells was assessed. However, they showed higher expression of DESMIN compared to BM-MSCs. After co-culture of hESC-PPs with
