Potential role of Sigma-1 receptor inhibition and ER stress-related pathways in upregulating definitive endoderm markers in human embryonic stem cells
https://ctrmrc.tums.ac.ir//article/Potential-role-of-Sigma–1-receptor-inhibition-and-ER-stress–related-pathways-in-upregulating-definitive-endoderm-markers-in-human-embryonic-stem-cells
Potential role of Sigma-1 receptor inhibition and ER stress-related pathways in upregulating definitive endoderm markers in huma Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) participate in stem cell proliferation, differentiation, and apoptosis. Sigma-1 receptor (S1R) is a unique ER chaperon protein that regulates ER stress and UPR. Here, we examine the effects of S1R inhibition on pluripotency and differentiation of human embryonic stem cells (hESCs). hESCs were treated
Incorporating NK Cells in a Three-Dimensional Organotypic Culture System for Human Skin Stem Cells: Modeling Skin Diseases and Immune Cell Interplay
https://ctrmrc.tums.ac.ir//مقالات-علمی/Incorporating-NK-Cells-in-a-Three–Dimensional-Organotypic-Culture-System-for-Human-Skin-Stem-Cells:-Modeling-Skin-Diseases-and-Immune-Cell-Interplay
Incorporating NK Cells in a Three-Dimensional Organotypic Culture System for Human Skin Stem Cells Modeling Skin Diseases and I Abstract Natural killer (NK) cells are a part of a sophisticated immune system that is necessary for the skin because it is a crucial organ that is continually exposed to environmental influences. Recent studies have shown that NK cell incorporation into three-dimensional (3D) organotypic culture systems for human skin stem cells provides a physiologically relevant envi
Epithelial cells/progenitor cells in developing human lower respiratory tract: Characterization and transplantation to rat model of pulmonary injury
https://ctrmrc.tums.ac.ir//article/Epithelial-cells⁄progenitor-cells-in-developing-human-lower-respiratory-tract:-Characterization-and-transplantation-to-rat-model-of-pulmonary-injury
Epithelial cells/progenitor cells in developing human lower respiratory tract Introduction For cell-based therapies of lung injury, several cell sources have been extensively studied. However, the potential of human fetal respiratory cells has not been systematically explored for this purpose. Here, we hypothesize that these cells could be one of the top sources and hence, we extensively updated the definition of their phenotype. Abstract Introduction For cell-based therapies of lung injury, sev
Standard Operating Procedure for Production of Mouse Brown Adipose Tissue-Derived Mesenchymal Stem Cells
https://ctrmrc.tums.ac.ir//article/Standard-Operating-Procedure-for-Production-of-Mouse-Brown-Adipose-Tissue–Derived-Mesenchymal-Stem-Cells
Over the past years, stem cell technology was heralded as a significant breakthrough of the century in scrutinizing the intricacies of human body biology and discovering different therapeutic approaches Abstract Over the past years, stem cell technology was heralded as a significant breakthrough of the century in scrutinizing the intricacies of human body biology and discovering different therapeutic approaches. Recently, adipose tissue, as a suitable source of harvesting mesenchymal stem cells,
Advancement of Organoid Technology in Regenerative Medicine
https://ctrmrc.tums.ac.ir//article/Advancement-of-Organoid-Technology-in-Regenerative-Medicine
To form organoids, stem cells are transplanted into the extracellular matrix. Organoids can help pave the road for precision medicine through genetic editing, pharmaceutical development, and cell therapy. Studies on the use of stem-cell-derived organoids in regenerative medicine, organoids as 3D culture models for EVs analysis, and organoids for precision medicine were included. Results According to the included studies, organoids have various origins, types, and applications in regenerative and
Human placenta-derived mesenchymal stem cells transplantation in
https://ctrmrc.tums.ac.ir//مقالات علمی/Human-placenta–derived-mesenchymal-stem-cells-transplantation-in-patients-with-acute-respiratory-distress-syndrome-(ARDS)-caused-by-COVID–19-(phase-I-clinical-trial):-safety-profile-assessment
patients with acute respiratory distress syndrome (ARDS) caused patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 (phase I clinical trial) safety profile assessment Acute respiratory distress syndrome (ARDS) is one of the most important causes of death in COVID-19 patients. Mesenchymal stem cells have been the subject of many clinical trials for the treatment of ARDS because of their immunomodulatory, anti-inflammatory, and regenerative potentials. The aim of this phase
Critical roles of cytokine storm and bacterial infection in patients with COVID‑19: therapeutic potential of mesenchymal stem cells
https://ctrmrc.tums.ac.ir//article/Critical-roles-of-cytokine-storm-and-bacterial-infection-in-patients-with-COVID‑19:-therapeutic-potential-of-mesenchymal-stem-cells
Critical roles of cytokine storm and bacterial infection in patients with COVID‑19 therapeutic potential of mesenchymal stem ce This virus can affect all systems of the body and its symptoms vary from a simple upper respiratory infection bacterial co-infection is another problem in COVID-19 which affects the prognosis of patients. pandemic, various approaches and therapeutics were introduced for treating COVID-19 patients. are not helpful enough, especially for complicated cases. Therefore, the
