Activation of CDKN2A and Up-regulation of PETN Are Key Features of Sunscreen Usage Versus Light Irradiation
https://ctrmrc.tums.ac.ir//مقالات-علمی/Activation-of-CDKN2A-and-Up–regulation-of-PETN-Are-Key-Features-of-Sunscreen-Usage-Versus-Light-Irradiation-
Abstract Introduction Sunscreen plays an unexpected role in protecting the skin against the harmful effects of sunlight. Skin protection against UV rays is highlighted as the main property of sunscreen. The present study investigated the core part of the molecular mechanism of skin protection by sunscreen. Methods Gene expression changes of the irradiated human skin with sunlight in the presence of sunscreen were mined from the Gene Expression Omnibus (GEO) database and analyzed to find the sign
Bridging the Gap Between Bone Marrow Transplantation and CAR-T Cell Therapy in Hematological Cancers
https://ctrmrc.tums.ac.ir//article/Bridging-the-Gap-Between-Bone-Marrow-Transplantation-and-CAR–T-Cell-Therapy-in-Hematological-Cancers
one marrow transplantation and chimeric antigen receptor T cell therapy have become two important treatment modalities for hematological malignancies, each having different mechanisms of action and therapeutic roles. Abstract Bone marrow transplantation and chimeric antigen receptor T cell therapy have become two important treatment modalities for hematological malignancies, each having different mechanisms of action and therapeutic roles. This chapter focuses on the chronological development an
Network analysis of liver cancer: a system biology approach
https://ctrmrc.tums.ac.ir//مقالات-علمی/Network-analysis-of-liver-cancer:-a-system-biology-approach
Aim Determining critical dysregulated proteins in liver cancer was the main aim of this study Abstract Aim Determining critical dysregulated proteins in liver cancer was the main aim of this study. Background Liver cancer is a common health problem characterized by difficulties in early diagnosis and rapid progression. Due to the lack of targeted drugs and the other features of the disease, the survival rate for patients is extremely low. Methods The related dysregulated proteins for liver cance
Cancer Chemo-Preventive Effects of Red Propolis: a System Biolog
https://ctrmrc.tums.ac.ir//مقالات علمی/Cancer-Chemo–Preventive-Effects-of-Red-Propolis:-a-System-Biology--Approach-
y Approach y Approach Results The results implied that six hub-bottlenecks including ACTB, GAPDH, HSP90AA1, HSPA8, HSP90AB1, and HSPA5 were present in the PPI network; however, only the last central protein was among DEPs. ClueGO CluePedia identified five related biological processes and three action types of their connections. Conclusion The proposed crucial proteins and their linked biological processes may represent as key players in the anticancer underlying mechanism of red propolis. Abstra
