Advancements in Degenerative Disc Disease Treatment: A Regenerative Medicine Approach
https://ctrmrc.tums.ac.ir//مقالات علمی/Advancements-in-Degenerative-Disc-Disease-Treatment:-A-Regenerative-Medicine-Approach
Regenerative medicine represents a transformative approach to treating nucleus pulposus degeneration and offers hope for patients suffering from chronic low back pain due to disc degeneration. By focusing on restoring the natural structure and function of the nucleus pulposus rather than merely alleviating symptoms, these innovative therapies hold the potential to significantly improve patient outcomes. Abstract Regenerative medicine represents a transformative approach to treating nucleus pulpo
Diabetic stem cell therapy and nanomedicine: advancements in treating diabetes
https://ctrmrc.tums.ac.ir//مقالات-علمی/Diabetic-stem-cell-therapy-and-nanomedicine:-advancements-in-treating-diabetes
Objectives In recent years, significant advancements have been made in the field of medical sciences, particularly in the treatment of diabetes using innovative methods. Diabetes, a chronic metabolic disorder considered by elevated blood glucose levels, disturbs millions of people worldwide. Abstract Objectives In recent years, significant advancements have been made in the field of medical sciences, particularly in the treatment of diabetes using innovative methods. Diabetes, a chronic metaboli
Critical roles of cytokine storm and bacterial infection in patients with COVID-19
https://ctrmrc.tums.ac.ir//مقالات علمی/Critical-roles-of-cytokine-storm-and-bacterial-infection-in-patients-with-COVID–19
This virus can affect all systems of the body and its symptoms vary from a simple upper respiratory infection to fatal complications including end-organ damage. Secondary bacterial co-infection is another problem in COVID-19 which affects the prognosis of patients. Therefore, the therapeutic benefits of mesenchymal stem cells, especially their antimicrobial activity, will help us understand how to treat COVID-19. Herein, mesenchymal stem cells may stop the immune system from becoming overactive
Long COVID and Stem Cell Therapy
https://ctrmrc.tums.ac.ir//مطالب-آموزشی/Long-COVID-and-Stem-Cell-Therapy
long COVID has more than 200 potential symptoms and can affect almost every organ in the body. With more than 65 million people now estimated to with this often-disabling condition worldwide, and numbers growing daily, there is a desperate need to understand the underlying biology driving it. To find out more about this long COVID infection – or post-acute sequelae SARS-CoV-2 (PASC), as it is increasingly being called – researchers at the US National Institute of Health did extensive testing on
Xeno-free protocol for GMP-compliant manufacturing of human fetal pancreas-derived mesenchymal stem cells
https://ctrmrc.tums.ac.ir//مقالات-علمی/Xeno–free-protocol-for-GMP–compliant-manufacturing-of-human-fetal-pancreas–derived-mesenchymal-stem-cells
To manufacture clinical-grade MSCs, animal-free culture protocols are preferred. A side-by-side comparison was made to evaluate the effect of each serum on proliferation rate, cell cycle, senescence, multi-lineage differentiation capacity, immunophenotype, and tumorigenesis of FPMSCs. Results Flow cytometry analysis and three-lineage differentiation ability demonstrated that fibroblast-like cells obtained from primary culture had MSCs' characteristics. In conclusion, HS can effectively replace F
Development and Validation of Type 2 Diabetic Zebrafish Model for Cell-Based Treatments
https://ctrmrc.tums.ac.ir//news/Development-and-Validation-of-Type-2-Diabetic-Zebrafish-Model-for-Cell�Based-Treatments/259152
Development and Validation of Type 2 Diabetic Zebrafish Model for Cell-Based Treatments Development and Validation of Type 2 Diabetic Zebrafish Model for Cell-Based Treatments Development and Validation of Type 2 Diabetic Zebrafish Model for Cell-Based Treatments diabetes mellitus can be categorized as one of the prolonged metabolic disorders that are associated withinappropriately elevated blood glucose levels. Among the subgroups of this disease, type 2 diabetes accounts for the most patients.
