Digging deep into molecular pathways: Investigating the effects of 9S-HOD on leukemia cells using a systems biology approach
https://ctrmrc.tums.ac.ir//مقالات علمی/Digging-deep-into-molecular-pathways:-Investigating-the-effects-of-9S–HOD-on-leukemia-cells-using-a-systems-biology-approach
Acute myeloid leukemia (AML) is a malignant disorder characterized by a poor prognosis. Current therapeutic approaches include chemotherapy, steroids administration, and blood transfusion. abstract Background Acute myeloid leukemia (AML) is a malignant disorder characterized by a poor prognosis. Current therapeutic approaches include chemotherapy, steroids administration, and blood transfusion. Previous studies have highlighted the potential anticancer property of 9-hydroxyoctadecadienoic acid (
Onion Extract on Cell Gene Expression Profile: a System Biology Approach
https://ctrmrc.tums.ac.ir//article/Onion-Extract-on-Cell-Gene-Expression-Profile:-a-System-Biology-Approach
Assessment of molecular mechanism of yellow onion extract on cell line Caco-2 was the aim of this study. The gene expression profiles of Caco-2 cells in the presence of yellow onion extract versus control cells were analyzed via GOE2R software. The significant differentially expressed genes (DEGs) were assessed via network analysis and the central nodes were enriched via gene ontology. Results Thirteen central nodes including JUN, ATF3, DUSP1 VEGF, CDKN1A, SNAI1, HSPB1, MCL1, SQSTM1, SREBF1, MAP
